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KMID : 0923620090090010012
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Immune Network
2009 Volume.9 No. 1 p.12 ~ p.19
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Heme Oxygenase-1: Its Therapeutic Roles in Inflammatory Diseases
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Pae Hyun-Ock
Chung Hun-Taeg
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Abstract
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Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV), the latter being subsequently converted into bilirubin (BR). HO-1, once expressed during inflammation, forms high concentrations of its enzymatic by-products that can influence various biological events, and this expression is proven to be associated with the resolution of inflammation. The degradation of heme by HO-1 itself, the signaling actions of CO, the antioxidant properties of BV/BR, and the sequestration of ferrous iron by ferritin all concertedly contribute to the anti-inflammatory effects of HO-1. This review focuses on the anti-inflammatory mechanisms of HO-1 actions and its roles in inflammatory diseases.
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KEYWORD
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heme oxygenase-1, carbon monoxide, bilirubin/biliverdin, inflammation, nuclear factor E2-related factor-2, mitogen-activated protein kinase
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